The Swiss Recipe for Containing Antimicrobial Resistance

Mirko Saam, co-founder and associate, Communication in Science Ltd, Geneva, Switzerland; Alexandre von Kessel, senior advisor, International Affairs Division, Federal Office of Public Health, Bern, Switzerland and Karin Wäfler, StAR project leader, Federal Office of Public Health, Bern, Switzerland

In 2015, the Swiss Federal Council adopted a national strategy to ensure the long-term efficacy of antibiotics, while preserving human and animal health. Developed through a consultation process involving all interested stakeholders (across public health, animal health, agriculture and the environment), this strategy is well matched with the WHO Global Action Plan on Antimicrobial Resistance. A range of measures are currently being implemented to monitor and contain antimicrobial resistance, appropriately use antibiotics, develop new drugs and diagnostic tools, and foster cooperation and education across the public and private sectors.

The Strategy on Antibiotic Resistance (1) was established jointly by the Federal Office of Public Health (FOPH), the Federal Food Safety and Veterinary Office (FSVO), the Federal Office for Agriculture (FOAG), the Federal Office for the Environment (FOEN), the regional authorities (cantons), and a wide array of stakeholders. Its content is therefore comprehensive and broadly supported, and grounded on a One Health approach.

Switzerland being a federal state, duties and responsibilities in the healthcare system are decentralized and divided among the federal, cantonal, and municipal levels, the cantons playing a vital role. Each of the 26 cantons has its own constitution and is responsible for licensing healthcare providers, coordinating hospital services, and subsidizing institutions. There are also multiple scientific institutions, which are active either at the federal or cantonal levels. These include universities, professional societies, associations and expert groups.

All these stakeholders and interest groups were involved in the preparation of the national strategy, with the aim of achieving a coordinated, cross-sectoral implementation. They all had the opportunity to express their viewpoints and experience in three workshops for devising the strategy. This process also took into account national AMR strategies of other countries and lessons learned in implementing them. Eventually, a public consultation was held before the strategy was adopted; the feedback from this process was summarized in a report and incorporated into the implementation.

Many of these stakeholders – in particular at cantonal level – are currently in charge of implementing the strategy. Four federal offices (FOPH, FSVO, FOAG and FOEN) are in charge of coordinating the activities, while the FOPH has the overall lead. In addition, two new permanent coordinating bodies based on the revised Law on Epidemics have been created to facilitate the cooperation between the Confederation and the cantons. In particular, a cross-sectoral One Health Coordination Body created in 2016 facilitates the adoption of any complementary laws or amendments (2).

The measures of the Strategy on Antibiotic Resistance are divided into eight fields, which are depicted in Figure 1. The following sections of this article briefly provide examples of activities currently being implemented, following the structure of WHO’s Global Action Plan on AMR.

 

National public awareness campaign

Switzerland’s inaugural National Antibiotic Awareness Week took place in November 2017. It aimed to inform stakeholders and the public about the dangers of antibiotic resistance and provide the latest information on regional and national projects (3). Universities, consumer associations and multiple stakeholder groups held their own events across the country. 

During this week, pharmaSuisse (the umbrella organization of pharmacists), the Swiss Medical Association (FMH) and the FOPH jointly launched the first nation-wide initiative to improve awareness about appropriate antibiotic use. After several focus groups, representatives of these three institutions prepared an information leaflet to be distributed to patients affected by an infectious disease, whether or not they are prescribed antibiotics. In 2018, general practitioners, specialists and a network of 1,500 pharmacies will distribute nearly a million of these leaflets, which are available in four languages. A short animated movie will provide complementary information on a dedicated website, where printed leaflets can be ordered free of charge (4). An evaluation of this information campaign is planned for the end of 2018.

Surveillance of AMR epidemiology and antibiotic use

From 2001 to 2006, a national research programme (NRP 49) mapped antibiotic resistance in Switzerland for the first time, in humans, animals and the environment. As a product of this research programme, the Swiss Centre for Antibiotic Resistance (anresis.ch) was established in 2004 to monitor AMR in the human population. Anresis.ch brings together a representative network of 22 microbiology laboratories covering more than 60% of inpatients and about 30% of outpatients. It maintains an open online database with updated resistance data, and publishes surveillance results monthly for the FOPH Bulletin and through a dedicated website for specialists (5). 

Figure 2 below illustrates the evolution in Switzerland of various forms of resistance in pathogenic bacteria responsible for invasive infections of the brain or bloodstream. 

The declaration of cases of resistance to last-resort antibiotics (carbapenems) is mandatory since 2016. A  National Reference Centre for Emerging Antibiotic Resistance was created in 2016 to help any laboratory – free of charge – in the identification of new or emerging forms of antibiotic resistance (6). The Swiss cantons have also set up a nationwide network of laboratories, which closely collaborate with the Federal authorities and the National Reference Centres on bacterial pathogens.

In the veterinary sector, a system aligned with European provisions (7) was established in 2006 to enable continuous monitoring of antimicrobial resistance in livestock animals and meat. Since 2009, data on sales of veterinary antimicrobials and results of resistance monitoring have been published yearly. More recently, a pilot project has been launched to further analyse resistant pathogens causing infections in livestock and pets.

Since 2013, data on the use of antibiotics in livestock and on resistance in animals and meat has been published every other year in a joint report, together with data from the human sector (8). The next Swiss Antibiotic Resistance Report (to be published in November 2018) will feature new surveillance results from 1) pilot projects to enhance surveillance of infections caused by resistant bacteria (e.g., in long-term healthcare facilities), 2) pathogens causing infections in livestock and pets, and 3) resistant microorganisms in rivers and lakes. The analysis of all these data in a One Health perspective will be strengthened.

Finally, in 2016 a five-year National Research Programme on Antimicrobial Resistance (NRP72) was launched; it aims at enhancing our knowledge of antibiotic resistance development and transmission (9).

Infection prevention and control

The NOSO Strategy for the monitoring, prevention and control of healthcare-associated infections was adopted in 2016 (10). Long before the adoption of this strategy, national guidelines were already published in this field, for instance for reprocessing medical devices and for antimicrobial prophylaxis in surgery. And more than half of all hospitals (164 at the latest count) already take part in a National Surgical Site Infection Surveillance Programme.

Currently, infection prevention and control policies and operational plans are available at all health facilities. They include hand hygiene measures and recommendations regarding isolation of colonized or infected patients. A network of public health and academic partners is in place to develop and evaluate these prevention interventions.

As for the Strategy on Antibiotic Resistance, one of the goals of the NOSO Strategy is to enhance the adoption of common practices across the country, and to fill in the gaps. For instance, there is no healthcare-associated infections prevention & control plan available for residential healthcare facilities. And it is still unclear whether (and how) such facilities may screen for multidrug-resistant organisms, or if they have specific plans to prevent and combat outbreaks caused by these pathogens.

These two closely related strategies will allow for the development of screening and outbreak management guidelines for multidrug-resistant organisms, and for the monitoring of adherence to those guidelines.

In the veterinary sector, there are officially endorsed animal health schemes for cattle and pigs. There are programmes in place, designed and delivered by stakeholders, which identify and promote good practice in livestock production and healthy animals as a way to reduce the use of antimicrobials. Animal health services have also stepped up their advisory services and activities to encourage infection prevention; as a result, a number of infectious diseases have been eradicated (e.g., enzootic pneumonia and actinobacillosis in pigs, and Salmonella enteritidis in chickens).

Finally, antibiotic residues in rivers and lakes are also monitored across the country. To curb the entry of these residues into the environment, wastewater treatment plants will be upgraded with additional treatment steps. With this upgrade, Switzerland is assuming a pioneering role, which has attracted considerable international interest.

Regulation to limit antibiotics use in agriculture

Back in 1999, Switzerland banned the addition of antibiotics to animal feed as growth promoters. Other legal requirements were introduced in 2004, such as a prohibition on the administration of antibiotics to livestock without a prescription by a veterinarian. A regulation on the use of antibiotics in veterinary medicine was adopted to curb the use of antibiotics for prophylactic treatment. Since 2016, the sale of critically important antimicrobials for human medicine has also been restricted in veterinary medicine.

Antibiotic pescription guidelines are available online for the most frequent infections affecting pigs and cattle (12). Currently, only “sales data” on antibiotics for veterinary use are available; a system to collect “veterinary prescription data” at species level is under construction.

Antibiotic stewardship programmes in hospitals and in the community

The Swiss Centre for Antibiotic Resistance also monitors antibiotic use. For inpatients, consumption has been monitored since 2006 through a sentinel network of hospital pharmacies. Yearly data from 65 hospitals (or hospital networks) are collected on a voluntary basis, representing 56% of acute care hospitals (excluding psychiatric and rehabilitation centres). The participating hospitals receive a yearly benchmarking report, allowing them to compare their results with those of similar-sized institutions. From 2018, this qualitative and quantitative feedback will be provided on a monthly basis.

Swiss hospitals are at very different stages of antibiotic stewardship implementation. Comprehensive programmes are only implemented in about one third of acute-care hospitals, which may be related to a lack of funding or personnel. Whereas prescription guidelines are available in the majority of them, levels of adherence to those guidelines are not systematically measured.

The roll-out of modular national antimicrobial stewardship guidelines is planned to improve the current situation and generalize stewardship programmes in Swiss hospitals, while offering flexibility to account for local healthcare structure and resources. Swissnoso is in charge of preparing these guidelines, in collaboration with hospital pharmacists, insurance representatives, the Swiss Medical Association (FMH), and the Swiss Hospital Association (13). The stewardship guidelines will be prepared in accordance with the Global Framework for Development & Stewardship to Combat Antimicrobial Resistance currently being developed by FAO, OIE and WHO.

In the outpatient setting, a comprehensive set of prescription guidelines for the most common infections in ambulatory care was issued in early 2018. Physicians’ adherence to these guidelines should now be promoted and monitored. These guidelines will hopefully have an impact on outpatient consumption, which is being monitored since 2013 and is based on information provided by 65% of all privately run pharmacies in Switzerland.

Financial support for the development of new antibiotics

The NRP 72, with a budget  of 20 million Swiss Francs, also aims at discovering novel antimicrobial molecules and developing rapid diagnostic techniques.

Box 1: International commitment

In May 2018, Switzerland joined the G20’s Global Collaboration Hub on AMR Research and Development, a new high-level global partnership aimed at maximizing the impact of existing and new initiatives in antimicrobial research and product development. With a view to promoting the R&D of new antibiotics and diagnostic tools at the international level, Switzerland extended in 2017 its financial support to the Global Antibiotic Research and Development Partnership GARDP, launched by the Drugs for Neglected Diseases initiative DNDi. Switzerland supported, with the international community, the adoption in 2015 of the Global Plan of Action to Combat AMR – developed by WHO in collaboration with FAO and OIE – and of the 2016 Political Declaration of the UN high-level meeting on AMR. Switzerland is participating in other international initiatives such as WHO’s Global Antimicrobial Resistance Surveillance System (GLASS), the Central Asian and Eastern European Surveillance of Antimicrobial Resistance (CAESAR) and the EU Joint Programming Initiative on Antimicrobial Resistance (JPIAMR). In a bid to strengthen international cooperation against AMR, Switzerland also joined the Global Health Security Agenda initiative, launched by the United States of America to combat communicable diseases. In this context it published in 2015 a comparative study of various national AMR strategies, with the aim to define best practices (14). Finally, to enhance the implementation of the national strategy, a Swiss interministerial delegation greatly appreciated the opportunity to visit the Netherlands (2016) and Norway (2017) to learn from the practical experiences of these countries in AMR control.

 

Conclusion

Despite all these positive efforts, there is still a great need for action; the global situation shows that isolated measures focusing on individual fields cannot provide a lasting solution to the problem of antibiotic resistance. The Joint External Evaluation of the capacity of Switzerland to prevent, detect and rapidly respond to public health threats, performed in 2017, identified several priority actions (15): 1) Develop screening and outbreak management guidelines for multidrug resistant organisms, and monitor adherence to those guidelines; 2) Enhance surveillance of antimicrobial resistant infections through pilot projects, and implement a national monitoring programme for animal pathogens; 3) Expand and consolidate monitoring of healthcare-associated infections; 4) Foster adherence to outpatient antibiotic prescription guidelines and to the Swiss national plan for stewardship in hospitals (to be released in 2018/19). 

 

Mirko Saam, MSc in Biology, is an external consultant who has been assisting the Federal Office of Public Health since 2014 for the implementation of the National Strategy on  Antibiotic Resistance. He has extensive technical expertise in biosafety and antimicrobial resistance, and is specialized in science communication related to environmental and health issues. He has worked for private companies, governmental agencies and for the Geneva University Hospitals.

Alexandre von Kessel, lawyer, LlM in public international law, is Senior Advisor at the International Affairs Division of the Swiss Federal Office of Public Health FOPH. He has been in charge since 2007 of international thematic issues related to HIV/AIDS, access to medicines, global health security and, in particular, antimicrobial resistance. His expertise in these areas has been instrumental in the development of the Swiss Health Foreign Policy. He has previously worked as Swiss coordinator for WHO at the FOPH and as health programme  officer at the Swiss Agency for Development and Cooperation.

Karin Waefler, MSc in Biology, is leader of the implementation process of the Swiss National Strategy against Antibiotic Resistance (StAR) at the Swiss Federal Office of Public Health (FOPH). Karin Waefler has been with the FOPH since 2005 and also served as project leader of public information on organ donation. Prior to working at the FOPH, she was leader of the further education programme in Nature and Environment at Sanu Future Learning AG SA, Managing Director of the Competence Center for New Media in Education – net4net at eduswiss/Bern University of Applied Sciences, and college preparatory high school teacher.

 

References

1. Strategy on Antibiotic Resistance Switzerland https://www.star.admin.ch/star/en/home/star/strategie-star.html 

2. https://www.blv.admin.ch/blv/fr/home/das-blv/organisation/kommissionen/unterorgan-one-health.html (webpage only available in French, German or Italian)

3. Strategy on Antibiotic Resistance 2017 Report https://www.bundespublikationen.admin.ch/cshop_mimes_bbl/8C/8CDCD4590EE41EE7ACCD26E7C74F203B.pdf

4. https://www.antibiotika-richtig-einsetzen.ch/en_GB/home 

5. http://infect.info/  

6. https://www.nara-antibiotic-resistance.ch/

7. Decision 2013/652/EU on the monitoring and reporting of AMR in zoonotic and commensal bacteria https://publications.europa.eu/en/publication-detail/-/publication/83e1934f-4d39-11e3-ae03-01aa75ed71a1/language-en 

8. Swiss Antibiotic Resistance Report 2016 www.bag.admin.ch/bag/de/home/service/publikationen/broschueren/publikationen-uebertragbarekrankheiten/publikation-swiss-antibiotic-resistance-report-2016.html 

9. National Research Programme 72 

http://www.nfp72.ch/en/

10. National Strategy for the Monitoring, Prevention and Control of Healthcare-Associated Infections (NOSO Strategy) https://www.bag.admin.ch/bag/en/home/service/publikationen/broschueren/publikationen-uebertragbare-krankheiten/publikation-nationale-strategie-noso.html 

11. Prescription of veterinary medicines https://www.blv.admin.ch/blv/fr/home/tiere/tierarzneimittel/fachgerechter-umgang-mit-tierarzneimitteln/verschreibung–abgabe-und-anwendung.html 

12. Guidance on appropriate antibiotic use in the veterinary sector www.vetpharm.uzh.ch/pdf_data/abscouttract.pdf

13. Evaluation of existing and desired antimicrobial stewardship activities and strategies in Swiss hospitals 

https://smw.ch/en/article/doi/smw.2017.14512/ 

14. Comparative study of various national AMR strategies

https://www.bag.admin.ch/dam/bag/fr/dokumente/int/foph-response-antimicrobial-resistance-threat.download/responsetotheantimicrobialresistancethreat.pdf.foph-response-antimicrobial-resistance-threat

15. World Health Organization (WHO) International Health Regulations (IHR 2005) JEE tool. http://apps.who.int/iris/handle/10665/204368