05 Introduction Dr Tedros Adhanom Ghebreyesus, Director-General, World Health Organization PDF

06 Editorial Dr Jean Carlet, President, WAAAR and Garance Upham, Vice-President, WAAAR PDF

08 Acknowledgements PDF

 

GLOBAL AND NATIONAL GOVERNANCE

10 AMR Control in discussion with… Dr Marc Sprenger, Director, Antimicrobial Resistance Secretariat, World Health Organization PDF

13 The Swiss recipe for containing antimicrobial resistance Mirko Saam, Co-Founder and Associate, Communication in Science Ltd, Geneva, Switzerland; Alexandre von Kessel, Senior Advisor, International Affairs Division, Federal Office of Public Health, Bern, Switzerland and Karin Wäfler, StAR Project Leader, Federal Office of Public Health, Bern, Switzerland   PDF

18 Sponsored Feature

Antimicrobial Resistance (AMR): Stressing the role of the health industry Martin Bernhardt, Head of Public Affairs Global Health, Sanofi PDF

20 The antimicrobial resistance situation in Iran: The National Initiative and R&D to face AMR Abed Zahedi Bialvaei, PhD student. Department of Microbiology, Iran University of Medical Science, Tehran, Iran; Dr Hossein Samadi Kafil, Assistant Professor, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Dr Mohammad Ahangarzadeh Rezaee, Associate Professor, Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Professor Mohammad Rahbar, Professor Iranian Reference Health Laboratory, Member, National Infection Control and Drug Surveillance System, Ministry of Health and Medical Education, Iran and Dr Mohammad Asgharzadeh, Professor of Molecular Biology, Drug Applied Research Center, Tabriz University  PDF

24 In order to protect antibiotics, which are a real treasure, we should list them as UNESCO World Heritage! Dr Jean Carlet, Founder and President, WAAAR, Architect of the National Plan to Preserve Antibiotics, France and Garance Upham, Vice-President, WAAAR PDF

26 AMR: A key focus of the upcoming 2019 Global Health Security Conference Adam Kamradt-Scott, Associate Professor, University of Sydney, Australia and Rebecca Katz, Associate Professor, Georgetown University, USA PDF

 

IPC AND SURVEILLANCE

30 Investing in infection prevention and control to contain antibiotic resistance: Progress is achievable Dr Benjamin J Park, Chief, International Infection Control Program, Office of the Director, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention (CDC), USA, Dr Denise Cardo, Director, Division of Healthcare Quality Promotion (DHQP), National Center for Emerging and Zoonotic Infectious Diseases, (CDC), USA and Dr Michael Bell, Deputy Director, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases (CDC), USA PDF

33 Supporter advertisement MedTech Europe PDF

34 Containing cross-transmission of multi-resistant bacteria: A priority for controlling resistance in healthcare centres Professor Vincent Jarlier, Bacteriology-Hygiene, University Paris 6; Infection Control Officer, Direction for Medical Affairs, Assistance Publique – Hopitaux de Paris; Vice-President of WAAAR and Dr Sandra Fournier, Central Infection Control Team, Assistance Publique-Hopitaux de Paris, Paris, France PDF

40 EU-JAMRAI: Europe fostering synergies to reduce the burden of AMR Belén Crespo, Director, Spanish Agency of Medicines and Medical Devices (AEMPS), Madrid, Spain; et al PDF

44 Supporter advertisement Hindustan Syringes & Medical Devices, India  PDF

45 ESCMID: A scientific society with a vision and a mission on antimicrobial resistance Professor Jesús Rodríguez-Baño, President, European Society of Clinical Microbiology and Infectious Diseases (ESCMID), and Head, Infectious Diseases Division, Hospital Universitario Virgen Macarena, Spain PDF

47 Political opportunities and R&D to combat MDR-TB Dr José Luis Castro, Executive Director; Paul Jensen, Director of policy and strategy and Grania Brigden, Life Prize Project Lead, the International Union Against Tuberculosis and Lung Disease (The Union) PDF

51 Addressing AMR in Madagascar: The experience of establishing a medical bacteriology laboratory at the Befelatanana University Hospital in Antananarivo Dr Saïda Rasoanandrasana, Head of Microbiology, Befelatanana University Hospital Laboratory, Madagascar; Dr Lalaina Rahajamanana, Head, Bacteriology Laboratory, Tsaralalàna Mother-Child University Hospital, Madagascar; Dr Camille Boussioux, Hospital Resident, Mérieux Foundation; Dr Marion Dudez, Medical Biologist, former Resident, the Mérieux Foundation in Madagascar; Dr Odile Ouwe Missi Oukem-Boyer, Mérieux Foundation Mali and Niger Country Manager, Acting Director General, Charles Mérieux Center for Infectious Disease in Mali; Luciana Rakotoarisoa, Mérieux Foundation Madagascar Country Manager; Dr Laurent Raskine, Head, Specialized Biology, Mérieux Foundation and Dr François-Xavier Babin, Director, Diagnostics and Health Systems, Mérieux Foundation PDF

56 The evidence base in antimicrobial resistance to inform decision-making – the need for epidemiology and surveillance Dr Ghada Zoubiane, Science Lead, Drug-Resistant Infections Priority Programme, Wellcome, UK; Professor Sharon Peacock, Clinical Microbiologist, London School of Hygiene and Tropical  Medicine, UK and Dr Timothy Jinks, Head, Drug-resistant Infections Priority Programme, Wellcome, UK PDF

 

ONE HEALTH

60 Establishing the importance of human and animal vaccines in preventing antimicrobial resistance Afifah Rahman-Shepherd, Research Analyst, Centre on Global Health Security, Chatham House UK; Nabila Shaikh, Research Assistant, Centre on Global Health Security, Chatham House; Dr Osman Dar, Project Director, Centre on Global Health Security, Chatham House and Professor David L Heymann, CBE, Head and Senior Fellow, Centre on Global Health Security, Chatham House PDF

65 Interventions to reduce antibiotic prescribing for upper respiratory tract infections in primary care settings, a major driver for antimicrobial resistance Dr Xiaolin Wei, Secretary General, The International Union Against Tuberculosis and Lung Disease (The Union); Associate Professor, Dalla Lana School of Public Health, University of Toronto, Canada and Zhitong Zhang, Director, China Global Health Research and Development, Shenzhen, China  PDF

69 To reduce the use of antibiotics follow a simple rule: Use them appropriately Jacques Acar, European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland  and Université Pierre-et-Marie-Curie, Paris, France and Mario Poljak, European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland and Faculty of Medicine, University of Ljubljana, Slovenia and ESCMID Immediate Past President and Publication Officer PDF

 

NGO ENABLERS

74 State-level AMR action plans in India: Progress  at a snail’s pace! Dr Abdul Ghafur, Coordinator, Chennai Declaration; Consultant in infectious diseases, Apollo Cancer Institute, Chennai, India PDF

78 Facing the challenges of and providing solutions for antimicrobial resistance in the intensive care unit: A call for action from the ANTARCTICA (ANTimicrobiAl Resistance CriTIcal CAre) Coalition Dr Jean Carlet,  President, World Alliance Against Antibiotic Resistance and Professor Jan de Waele, Intensivist, Ghent University Hospital, Belgium PDF

 

RESEARCH & DEVELOPMENT

82 CARB-X is a new approach to accelerating promising research into new antibiotics, therapeutics, diagnostics, vaccines and devices … and it is making progress Professor Kevin Outterson, Executive Director and Principal Investigator, CARB-X, Boston University, Boston, USA PDF

85 A not-for-profit antibiotic developer – The Global Antibiotic Research and Development Partnership Dr Manica Balasegaram, Director, GARDP, Geneva, Switzerland; Peter Beyer, Senior Adviser, World Health Organization, Geneva, Switzerland and Jean-Pierre Paccaud, Business Development and Corporate Strategy Director, GARDP, Geneva, Switzerland PDF

89 Evolutionary biology as a tool to combat antimicrobial resistance Dr Alasdair T M Hubbard, Postdoctoral Research Associate, Liverpool School of Tropical Medicine, UK and Dr Adam P Roberts, Lead AMR Research, Department of Parasitology and Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, UK PDF

 

ALTERNATIVES

94 Basic neglected research against AMR: What if plants provided a solution? Akram M Salam, PhD candidate in Molecular and Systems Pharmacology, Emory University, USA  and Dr Cassandra L Quave, Assistant Professor of Dermatology and Human Health, Emory University, Curator, Emory University Herbarium, USA PDF

99 Phages as antibacterial agents: Laboratory training in developing countries Dr Tobi E Nagel, Founder and President, Phages for Global Health, USA; Dr Benjamin K Chan, Associate Research Scientist, Yale University, USA; Dr Janet Y Nale, Postdoctoral Research Associate, University of Leicester, UK and Professor Martha RJ Clokie, Professor of Microbiology, University of Leicester, UK  PDF

104 Complex bone and joint infections: Treatment with bacteriophages as salvage therapy Professor Tristan Ferry, Hospices Civils de Lyon; Claude Bernard Lyon 1 University and Centre de Références des Ioa Complexes (CRIOAc), Lyon, France; Dr Gilles Leboucher, Hospices Civils de Lyon; Professor Sébastien Lustig, Hospices Civils de Lyon; Dr Fabien Boucher, Hospices Civils de Lyon and CRIOAc Lyon, France; Dr Guy-Charles Fanneau De La Horie and Dr Jérôme Gabard, Pherecydes Pharma, France; Professor Frédéric Laurent, Hospices Civils de Lyon, Claude Bernard Lyon 1 University and Centre de Références des Ioa Complexes (CRIOAc) Lyon, France;  on behalf of the Lyon BJI Study Group, France, and Cindy Fevre, Pherecydes Pharma, France PDF

 

INVESTMENT AND SOCIETY

112 AMR Control in discussion with… Dr Enis Bariş, Practice Manager, Europe and Central Asia Health, Nutrition and Population Global Practice, World Bank PDF

114 Anthropology’s contribution to AMR control Laurie Denyer Willis and Clare I R Chandler, Department of Global Health and Development, London School of Hygiene & Tropical Medicine, UK PDF

117 Appendix 1: WAAAR

IBC Supporter advertisement: Becton, Dickenson and Company PDF